RE: specific amino acid restriction does the same thing as calorie restriction?

From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Tue Apr 22 2003 - 09:30:14 MDT

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    On Tue, 22 Apr 2003, Reason wrote:

    > Here's something from the CR Society list. They've chewed this topic over
    > before, apparently.

    Though I haven't read the articles Reason points out --
    it would be very interesting to look at the synthesis
    pathway(s) for glutathione -- there may be some molecules
    that one could provide to still allow the optimal synthesis
    of glutathione but not repress the up-regulation of
    protein recycling that methionine restriction may cause.

    Notes:
    - I don't know if methionine is required for glutathione synthesis.
    - I don't know if glutathione can be absorbed and distributed directly
      from food intake.
    - It may be that N-acetyl-cysteine (NAC) could be the required amino acid
      for glutathione synthesis.
    - I don't think we know if NAC restriction on top of methionine restriction
      produces additive effects in terms of up-regulating protein turnover.

    Robert

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