RE: specific amino acid restriction does the same thing as calorie restriction?

From: Reason (reason@exratio.com)
Date: Tue Apr 22 2003 - 03:44:46 MDT

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    Here's something from the CR Society list. They've chewed this topic over
    before, apparently.

    Reason
    http://www.exratio.com/

    ------------------------------

    Date: Mon, 21 Apr 2003 05:15:40 -0400
    From: Dean Pomerleau
    Subject: Re: EXI: specific amino acid restriction does the same thing as
             calorie restriction?

    Reason wrote:
    > These topics from the ExI BBS are worth a look from a CR point of view. A
    > lot of interesting discussion on a recent paper that claims CR-like
    > results
    > for a non-CR diet that tinkers with amino acid proportions.
    >

    The subject of Methionine Restriction, the primary topic of this article,
    has been discussed several times recently on the CR list, with much more
    rigor than it appears to have been in the extropian thread, thanks mostly to
    our man Michael Rae. Here is a link to a very interesting thread on the
    subject (found using an archive search of "methionine" with the author field
    containing "cadvision" (MR's internet service provider):

    http://tinyurl.com/9ya6

    (Long:
    http://lists.calorierestriction.org/cgi-bin/wa?A2=ind0208&L=crsociety&P=R182
    70 )

    where Michael expresses optimism on the possibility of life extension via
    methionine restriction, but also recommends *against* trying it for now -
    too risky.

    But later, in the following post, he seems to have tempered his optimism. In
    it he points to evidence posted to sci.l-e by Steve Herris that methionine
    restriction might be a form of "crypto CR" - i.e. works by reducing food
    intake of animals:

    http://tinyurl.com/9y9y

    (Long:
    http://lists.calorierestriction.org/cgi-bin/wa?A2=ind0211&L=crsociety&P=R292
    09 )

    In short, it appears the met-restricted animals were *offered* as much food
    as the AL fed controls. But as a result of lifelong met-restriction, their
    growth was stunted. As a result of their stunted growth they likely ate
    less food than their AL brethren (despite being offered as much), and may
    have garnered the benefits of CR through this reduced food intake.

    These discussions were took place at least 6 months ago, and perhaps Michael
    has more to say about the subject of methionine restriction now.

    --Dean

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