From: R. Coyote (coyyote@hotmail.com)
Date: Sun Apr 20 2003 - 21:35:38 MDT
It is widely believed that most orally ingested enzymes are destroyed by the
digestive juices prior to being absorbed. However, there is evidence that
significant amounts of bromelain can be absorbed intact.
Orally administered bromelain is absorbed intact from the intestine. Because
of its proteolytic activity, about 50% of bromelain is rapidly complexed
with an antiproteinase, namely alpha-2-macroglobulin (AMG). Proteolytic
activity is maintained within this protective molecule, but reduced. In a
recent human study, plasma half-life was determined to be 6-9 h. Orally
administered bromelain is absorbed at a rate of 40% in animal studies.
Izaka K, Yamada M, Kawano T, Suyama T. Gastrointestinal absorption and
anti-inflammatory effect of bromelain. Jpn J Pharmacol 1972;22:519-34.
Seligman B. Oral bromelains as adjuncts in the treatment of acute
thrombophlebitis. Angiology 1969;20:22-6.
Seltzer AP. Minimizing post-operative edema and ecchymoses by the use of an
oral enzyme preparation (bromelain). EENT Monthly 1962;41:813-7.
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(Ananas comosus) and its clinical application. An update. J Ethnopharmacol
1988; 27: 191-203. (Oral)
Effects of oral bromelain administration on the impaired immunocytotoxicity
of mononuclear cells from mammary tumor patients.
Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR
Oral bioavailability of bromelain and trypsin after repeated oral
administration of a commercial polyenzyme preparation
Mai I., Donath F., Maurer A., Bauer S., Roots I.
Institut für Klinische Pharmakologie, Charité, Berlin
European Journal of Clinical Pharmacology 1996, 50 (6), 548.
Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol
Life Sci 2001;58:1234-45.
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burn wounds. Burns 2000;26:207-22.
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Surg 1996;97:233-40.
Herr SM. Herb-Drug Interaction handbook, 2nd ed. Nassau (NY): Church Street
Books; 2002
Castell JV, et al. Intestinal absorption of undegraded proteins in men:
presence of bromelain in plasma after oral intake. Am J Physiol
1997;273:G139-46.
Desser L, et al. Oral enzymes as additive cancer therapy. Int J
Immunotherapy 2001;17:153-61.
Desser L,et al. Oral therapy with proteolytic enzyes decreases excessive
TGF-beta levels in human blood. Cancer Chemother Pharmacol 2001;47:S10-5.
11. Smyth RD, Brennan R, Martin GJ. Studies establishing the absorption of
bromelains (proteolytic enzymes) from the gastrointestinal tract. Exp Med
Surg. 1964;22: 46-59.
12. Miller JM, Ginseberg M, McElfatrick GC, et al. The administration of
bromelain orally in the treatment of inflammation and edema. Exp Med Surg.
1964;22:293-299.
13. Castell JV, Friedrich G, Kuhn CS, et al. Intestinal absorption of
undegraded proteins in men: presence of bromelain in plasma after oral
intake. Am J Physiol. 1997;273:G139-G146.
----- Original Message -----
From: "Hal Finney" <hal@finney.org>
To: <extropians@extropy.org>
Sent: Sunday, April 20, 2003 6:35 PM
Subject: Re: specific amino acid restriction does the same thing as calorie
restriction?
> coyyote@hotmail.com writes:
>
> > Bromelain: Is a proteolytic digestive enzyme that can enhance absorption
> > of protein. It also affects protein turnover
>
> It might help with digestion in some cases, although I don't think most
> people need help in that area. However bromelain is itself a protein
> and will be broken up in the digestive system just like all the others.
> Orally consumed bromelain will get into your body to do anything to
> protein turnover. As far as the rest of your system is concerned,
> it's just a source of amino acids like all other proteins.
>
> Hal
>
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