From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Sun Apr 20 2003 - 06:05:48 MDT
On Sun, 20 Apr 2003, gts wrote:
> Am I looking at the right article? Perhaps not.
> However if I am looking at the right article then why
> is no one here discussing the properties of
> methionine, cysteine or tryptophan?
[big snip]
Yes you are looking at the right articles. And your
comments would generally be correct as far as I know
without digging into the textbooks. I too generally
agree with the comments about considering single amino
acids as "drugs" though I'm opposed to the FDA regulating
them.
The problem I see with limiting methionine or cysteine
is that they are primary sources of sulfur, which I
believe is an essential component of glutathione which
is a major antioxidant. So perhaps one might want to
limit those but supplement with either glutathione or
N-acetyl-cysteine (though that might defeat the
purpose of cysteine restriction).
The problem I see is that I don't believe we know yet
precisely where in the pathways the "detection" of
low essential amino acids are and how they upregulate
protein recycling. But I'd guess we will know that
within this decade. It seems likely that they should
be highly conserved biochemical detection/regulation
systems.
Robert
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