From: Rafal Smigrodzki (rafal@smigrodzki.org)
Date: Sat Feb 15 2003 - 22:13:19 MST
----- Original Message -----
From: "gts" <gts_2000@yahoo.com>
To: <extropians@extropy.org>
Sent: Saturday, February 15, 2003 3:09 PM
Subject: Re: Performance enhancement with selegiline
> For those of you with open minds and optimistic attitudes, here is yet
> *another* research abstract about the benefits of selegiline. (I think
I've
> posted at least a dozen such abstracts now!)
### Another meaningless dog study.
-----------------------
>
> Rafal, as far as I can tell you are not interested in fairly evaluating
> selegiline (deprenyl). You seem entrenched in your close-minded role as
> nay-sayer. I'm quite sure there is nothing I could post here short of
> absolute proof positive that would persuade you of the immense promise of
> this drug for life-extension and cognitive enhancement purposes. Oh well!
> I'm not posting these messages here only for your benefit.
### Find a placebo-controlled, preferably multicenter, definitely
double-blind trial with positive results and I'll join your camp. All else
is a waste of time.
Until then, whoever wants to spend his cash on this drug will do it without
my blessing.
----------------------
>
> Your attitude by the way also argues against the practice of calorie
> restriction in humans, despite its numerous successes in prolonging life
in
> lab animals.
### Well, there is evidence that caloric restriction reduces blood pressure,
insulin resistance, lipid peroxidation, and some other markers of aging in
humans. This is not proof of CR efficacy but strong-willed adventurers might
find these data compelling enough. On the other hand we have to remember the
lesson of the reduction of PVC's - there were drugs widely prescribed
against cardiac arrhythmias, because the effectively prevented PVC's, which
were considered markers of a tendency to have arrhythmias. Unfortunately,
later on it turned out that these drugs were also causing the patients to
die. Or, the same story with HRT - prescribed on the basis of markers, and
symptomatic relief, but now proven to actually kill patients.
Buyer beware.
Rafal
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