Re: Performance enhancement with selegiline

From: Rafal Smigrodzki (rafal@smigrodzki.org)
Date: Sat Feb 15 2003 - 22:13:19 MST

  • Next message: Rafal Smigrodzki: "Re: Performance enhancement with selegiline"

    ----- Original Message -----
    From: "gts" <gts_2000@yahoo.com>
    To: <extropians@extropy.org>
    Sent: Saturday, February 15, 2003 3:09 PM
    Subject: Re: Performance enhancement with selegiline

    > For those of you with open minds and optimistic attitudes, here is yet
    > *another* research abstract about the benefits of selegiline. (I think
    I've
    > posted at least a dozen such abstracts now!)

    ### Another meaningless dog study.

    -----------------------

    >
    > Rafal, as far as I can tell you are not interested in fairly evaluating
    > selegiline (deprenyl). You seem entrenched in your close-minded role as
    > nay-sayer. I'm quite sure there is nothing I could post here short of
    > absolute proof positive that would persuade you of the immense promise of
    > this drug for life-extension and cognitive enhancement purposes. Oh well!
    > I'm not posting these messages here only for your benefit.

    ### Find a placebo-controlled, preferably multicenter, definitely
    double-blind trial with positive results and I'll join your camp. All else
    is a waste of time.

    Until then, whoever wants to spend his cash on this drug will do it without
    my blessing.

    ----------------------

    >
    > Your attitude by the way also argues against the practice of calorie
    > restriction in humans, despite its numerous successes in prolonging life
    in
    > lab animals.

    ### Well, there is evidence that caloric restriction reduces blood pressure,
    insulin resistance, lipid peroxidation, and some other markers of aging in
    humans. This is not proof of CR efficacy but strong-willed adventurers might
    find these data compelling enough. On the other hand we have to remember the
    lesson of the reduction of PVC's - there were drugs widely prescribed
    against cardiac arrhythmias, because the effectively prevented PVC's, which
    were considered markers of a tendency to have arrhythmias. Unfortunately,
    later on it turned out that these drugs were also causing the patients to
    die. Or, the same story with HRT - prescribed on the basis of markers, and
    symptomatic relief, but now proven to actually kill patients.

    Buyer beware.

    Rafal



    This archive was generated by hypermail 2.1.5 : Sat Feb 15 2003 - 22:15:46 MST