LE: Life Extension Update 2000.10.13

From: Technotranscendence (neptune@mars.superlink.net)
Date: Fri Oct 13 2000 - 20:57:39 MDT

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caused in some by cystic fibrosis gene; PROTOCOL: Allergies; FEATURED
PRODUCTS OF THE WEEK: N-acetyl cysteine capsules, Vitamin C Capsules;

Sinusitis caused in some by cystic fibrosis gene

Approximately 14% of Americans suffer from sinusitis, an inflammation of
the mucous membranes of the sinuses frequently found in allergy sufferers.
Sinusitis is a common complaint, leading to 11.6 million physician's
office visits in 1991 alone, and in some cases causing sufferers to seek
out surgical intervention. The condition is poorly understood. The October
11 issue of the Journal of the American Medical Association revealed that
in some individuals, the genetic mutations that cause the disease cystic
fibrosis causes chronic sinusitis in others. Cystic fibrosis (CF) is an
inherited disease characterized by an alteration in the lungs' mucous
membranes, leading to an overproduction of thick, sticky mucous. The
disease has been found to be caused by mutations in the cystic fibrosis
transmembrane regulator gene, or CFTR, which regulates the cell membrane's
flow of water and salt. Because CF patients suffer from chronic sinusitis,
researchers at Johns Hopkins sought to determine if sinusitis patients
without CF could have similar CTFR mutations.

The study, partly funded by the National Institute of Diabetes and Kidney
Diseases (NIAID) of the National Institutes for Health, examined the DNA
of 147 sinusitis patients who did not have CF, and found the cystic
fibrosis mutation in ten of them, a rate five times that of the rest of
the population.

Marshall Plaut, MD of the NIAID commented, "The study is among the first
to investigate the genetic basis of chronic sinusitis, a common and
troublesome disorder. It provides new insights into the cause of the
disease in some people and points to new strategies for diagnosis and
treatment. It represents a new and important research direction."


Allergies are abnormal immune reactions to specific agents known as
antigens or allergens. Examples of common allergens are foods, drugs,
pollens, dust mites, mold spore, animal danders, feathers, and insect
venoms, as well as other substances which nonallergic people find
relatively nondangerous with usual exposure.

Allergies may also develop when an otherwise innocent substance has
significant contact with an already inflamed surface (sensitization), such
as from a viral infection or exposure to irritants, and becomes involved
in the immune response. Thereafter, repeat exposure to such a substance
may evoke an allergic response with the release of a histamine and a
variety of proinflammatory substances, including enzymes, leukotrienes,
and interleukins, and the creation of damaging free radicals. The
multiplicity of these proinflammatory substances explains why single
medications such as antihistamines often fail to completely control

The number of supplements required to suppress allergy symptoms can appear
daunting, but the health benefits of consuming these nutrients include
reductions in the risk of cardiovascular disease, cancer, dementia,
osteoporosis, arthritis, and a host of degenerative diseases associated
with normal aging. Therefore, while the objective of the allergy patient
is immediate relief, the use of nutritional supplements can provide a
long-term solution in treating the underlying cause of the chronic allergy
problem and helping to maintain an optimal state of health.

One or more of the following nutritional supplements should be tried by
the allergy sufferer for at least 2 months:
1. Life Extension Mix, 3 tablets, 3 times a day.
2. GLA from borage oil, 1500 mg a day, along with at least 3000 mg a day
of the omega-3 fatty acids from fish, flax, or perilla oils. (Six to
twelve capsules a day of Udo's Choice multi-oil blend may also be used.)
3. CoQ10 with tocotrienols, 30 mg, 3 times a day.
4. Vitamin C, 3000 to 9000 mg a day (Life Extension Mix provides about
2500 mg of vitamin C).
5. Magnesium, 500 to 1500 mg a day, taken with 900 to 1000 mg of calcium.
6. DHEA, 25 mg, twice a day (refer to DHEA Replacement Therapy protocol
for safety precautions).
7. NAC, 600 mg a day, in addition to the 600 mg already contained in Life
Extension Mix.
8. Life Flora, 1 capsule 3 times a day for a week, then reduce dose to 1
capsule a day thereafter. Supplementation with 5000 mg of FOS powder will
help protect the beneficial bacterial contained in Life Flora in your gut.
9. Grape seed-skin extract, 100 mg, 3 times a day.
10. Nettle leaf extract, 750 mg a day.

N-acetyl cysteine

N-acetyl-cysteine, a sulfur containing free form amino acid, is a
precursor for glutathione in the body and has been used to boost
glutathione levels in cells. N-acetyl-cysteine is a more stable and
effective antioxidant than L-cysteine, being the acetylated form of
cysteine which provides for better absorption. It is an antioxidant that
has been used to combat viruses, as a liver protectant and to break up
pulmonary and bronchial mucus.

Vitamin C Capsules

Each hard gelatin capsule contains 1000 mg of pure crystalline ascorbic
acid, providing 1,666% of the US RDA. Use an antacid with this form of
Vitamin C if you have an ulcer. Vitamin C is an important antioxidant,
helpful in lowering cholesterol and preventing heart disease, improving
immune function, maintaining healthy skin and blood vessels, accelerating
healing, and reducing allergic reactions.

BOOK: The Power to Destroy
By Senator William V Roth, Jr and William H Nixon

The Internal Revenue Service has powers unrivaled by any agency of our
federal government, powers that can irrevocably affect the lives of more
than 200 million American taxpayers. Since its founding, the agency's use-
-and abuse--of these powers has spawned controversy and frequent calls for
reform. But for years, the IRS had rebuffed these efforts, openly
resisting all attempts to alter the agency's structure or policies and
engaging in acts that have intimidated those who sought change.

In 1997 William Roth spearheaded the most extensive tax collection reform
effort in modern history. He initiated an investigation into the IRS and
chaired congressional hearings that uncovered horrifying stories of abuses
against taxpayers that shocked the nation. The legislation that
resulted--the Internal Revenue Service Restructuring Act, which passed the
Senate unanimously in May 1998--has ushered in what The New York Times
called "the most sweeping changes in decades to an agency whose very
function has long made it the most reviled in government."

Part expose' of a government agency gone grievously wrong, part history of
a radical and unprecedented reform effort, and part empowering handbook
for understanding the new tax laws, The Power to Destroy is a provocative
book every taxpaying America needs to read.


If you haven't already joined, readers of Life Extension Update may wish
to avail themselves of the many benefits of membership in the Life
Extension Foundation. For a $75.00 yearly membership fee, Life Extension
Foundation members receive 25% off all product purchases, a twelve month
subscription to Life Extension Magazine which you will receive in advance
of the posting of the online version; a copy of the Disease Prevention and
Treatment Protocols book, a 945 page book that is the only book available
that makes specific recommendations about combining mainstream therapies
with nutrients, hormones, and unique medications; and three informative
booklets: The Physician's Guide to Life Extension Drugs, The Directory of
Innovative Medical Clinics and The Directory of Innovative Doctors.
Members of the Life Extension Foundation support important research in the
field of gerontology that may one day extend our lives.

If you have any questions concerning this ezine or other life extension
topics, email me at ddye@lifeextension.com

For longer life,

Dayna Dye
Editor, Life Extension Update
Life Extension Foundation

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