From: John Clark (
Date: Sat Aug 05 2000 - 11:18:29 MDT

>From the August 4 2000 issue of Science:

"In 1994, Zakian and collaborator Vincent Schulz reported that the protein
Pif1p keeps telomeres from lengthening. It remained unclear, however,
how Pif1p accomplished that feat. There are many natural substances
that could inhibit telomere lengthening in indirect ways, Zakian said.
The new paper shows that Pif1p acts on the telomerase pathway itself
and interacts directly with telomeric DNA, a potentially attractive feature
for drug developers."

        John K Clark

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