Re: AGING: Accumulation of DNA damage

From: Damien Broderick (
Date: Mon Jul 10 2000 - 21:47:01 MDT

At 04:57 PM 10/07/00 +0200, Joao Pedro de Magalhaes wrote:

>Finally, there was a Korean team that
>also used in vitro aged cells and found that they were better for cloning.
>Of course that you can argue that in vitro aged cells are not the same thing
>as in vivo

Well, oooobviously they're not. Except for telomere length, presumably,
which either gets reset or isn't sufficiently degraded (a la Dolly) to
prevent a generation or two of cloning. (They're not exposed to the
accumulating damage and wear&tear due to being part of a metabolising soma.)

Damien Broderick

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