Re : AGING: Accumulation of DNA damage

From: Joao Pedro de Magalhaes (
Date: Tue Jul 18 2000 - 08:12:51 MDT


Robert Bradbury wrote:
>>From "DNA Repair & Mutagenesis", E. C. Freidberg et al, 1995, pg 216:
> "Studies first carried out with mammalian cells demonstrated that
> nucleotide excision repair of DNA occurs preferentially in actively
> transcribed genes (see Chapters 7 & 8). A similar phenomenon has
> been demonstrated in E. Coli, for which it has been shown that in
> actively transcribed DNA nucelotide excision repair has a pronounced
> bias for the transcribed strand."

Nice. Of course more evidences are necessary for conclusions to be taken but
now you're starting to have a case.


Joao Pedro de Magalhaes
The University of Namur (FUNDP)
Unit of Cellular Biochemistry & Biology
Rue de Bruxelles, 61
B-5000 Namur BELGIUM

Fax: + 32 81 724135
Phone: + 32 81 724133
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