Carnitine and lipoic acid make old rats youthful

Date: Mon Feb 25 2002 - 12:39:38 MST

J. Hughes reported on this study on a transhumanist list:

   Berkeley - Two dietary supplements straight off the health food
   store shelf put the spark back into aging rats, and might do the
   same for aging baby boomers, according to a study at the University
   of California, Berkeley, and Children's Hospital Oakland Research

   A team of researchers led by Bruce N. Ames, professor of molecular and
   cell biology at UC Berkeley, fed older rats two chemicals normally
   found in the body's cells and available as dietary supplements:
   acetyl-L-carnitine and an antioxidant, alpha-lipoic acid.

   In three articles in the February 19 issue of Proceedings of the
   National Academy of Sciences, Ames and his colleagues report the
   surprising results. Not only did the older rats do better on memory
   tests, they had more pep, and the energy-producing organelles in
   their cells worked better.

   "With the two supplements together, these old rats got up and did the
   Macarena," said Ames, also a researcher at Children's Hospital Oakland
   Research Institute (CHORI). "The brain looks better, they are full
   of energy - everything we looked at looks more like a young animal."

The abstract is at,
along with a link to the full paper if you subscribe.


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