From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Fri Apr 25 2003 - 16:03:36 MDT
Aubrey & Rafal (I think) are discussing...
> >> Is there some alpha-synuclein in lysosomes simply because stuff ends
> >> up in lysosomes, or is it's presence in the lysosomes the mechanism
> >> of its detrimental action? This has not been answered so far, AFAIK.
> >
> > I agree, but who cares? -- the only thing that matters is whether NON-
> > lysosomal alpha-synuclein is bad for cells, and no one has postulated
> > any way that it could be.
>
> ### You lost me here. For the outcome of a xenohydrolase treatment it
> definitely matters whether the lysosomal aggregates are detrimental or not.
Ask the universe and it delivers...
Protein Interactions Demonstrate That Alzheimer's And Parkinson's Disease
May Share A Common Fiber
http://www.sciencedaily.com/releases/2003/04/030425072025.htm
Apparently work by Forman MS, et al, in Science this week from the Univ.
of Penn.
Giasson B.I. et al., Initiation and Synergistic Fibrillization of Tau and
Alpha-Synuclein, Science 2003 300:636-640
http://www.sciencemag.org/cgi/content/abstract/300/5619/636
I don't have access to Science otherwise I'd post the abstract.
It also doesn't appear to have made it into PubMed yet...
But interesting how that turns up in the middle of the discussion...
R.
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