Yokozawa T. Fujioka K. Oura H. Nonaka G. Nishioka I. Institution
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Effects of rhubarb tannins
on renal function in rats with
Nippon Jinzo Gakkai Shi. Japanese Journal of Nephrology. 35(1):13-8, 1993 Jan.
The effects of tannins purified from Rhei Rhizoma on various parameters of renal function were investigated in rats with adenine-induced renal failure. The glomerular filtration rate, renal plasma flow and renal blood flow were significantly increased in rats given (-)-epicatechin 3-O-gallate at a dose of 5 or 10 mg/kg body weight/day for 24 days. Administration of 5 mg of procyanidin B-2 3,3'-di-O-gallate also led to a significant increase in renal functional parameters. However,
unlike the former two components, procyanidin C-1 3,3',3''-tri-O-gallate caused aggravation of renal function.