Authors
Yokozawa T. Fujioka K. Oura H. Nonaka G. Nishioka I.
Institution
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical
University, Japan.
Title
Effects of rhubarb tannins
on renal function in rats with
renal failure.
Source
Nippon Jinzo Gakkai Shi. Japanese Journal of Nephrology. 35(1):13-8, 1993
Jan.
Abstract
The effects of tannins purified from Rhei
Rhizoma on various parameters of renal
function were investigated in rats with adenine-induced
renal failure. The glomerular filtration rate,
renal plasma flow and renal blood flow were
significantly increased in rats given (-)-epicatechin 3-O-gallate at a dose
of 5 or 10 mg/kg body weight/day for 24 days. Administration of 5 mg of
procyanidin B-2 3,3'-di-O-gallate also led to a significant increase in
renal functional parameters. However,
unlike the former two components, procyanidin C-1 3,3',3''-tri-O-gallate
caused aggravation of renal function.