Authors
Yokozawa T. Dong E. Oura H.
Institution
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical
University, Japan.
Title
Proof that green
tea tannin suppresses the increase in the
blood methylguanidine level associated with renal failure.
Source
Experimental & Toxicologic Pathology. 49(1-2):117-22, 1997 Feb.
Abstract
The effects of a green tea
tannin mixture and its individual tannin
components on methylguanidine were examined in rats with renal failure. The
green tea tannin mixture
caused a dose-dependent decrease in methylguanidine, a substance which
accumulates in the blood with the progression of renal failure. Among
individual tannin components, the effect was most
conspicuous with (-)-epigallocatechin 3-O-gallate and (-)-epicatechin
3-O-gallate, while other components not linked to gallic acid showed only
weak effects. Thus, the effect on methylguanidine was found to vary among
different types of tannin.