Yokozawa T. Dong E. Oura H.
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Proof that green
tea tannin suppresses the increase in the blood methylguanidine level associated with renal failure. Source
Experimental & Toxicologic Pathology. 49(1-2):117-22, 1997 Feb. Abstract
The effects of a green tea
tannin mixture and its individual tannin components on methylguanidine were examined in rats with renal failure. The green tea tannin mixture
caused a dose-dependent decrease in methylguanidine, a substance which accumulates in the blood with the progression of renal failure. Among individual tannin components, the effect was most conspicuous with (-)-epigallocatechin 3-O-gallate and (-)-epicatechin 3-O-gallate, while other components not linked to gallic acid showed only weak effects. Thus, the effect on methylguanidine was found to vary among different types of tannin.