Re : Life Span Extension

From: Joao Pedro de Magalhaes (
Date: Tue Nov 13 2001 - 08:56:31 MST


Robert J. Bradbury wrote:
>The fact that we have accumulating evidence for circulating
>(or migrating) stem cells playing a role in everything from
>angiogenesis (required for wound healing -- something that
>declines with age) to memory formation is beginning to point
>a significant finger at cellular scenescence as being a major
>player in aging.

Most stem cells in humans appear to have telomerase and whether they have
cellular senescence like fibroblasts is still a cause for debate.

Robert, do you know the theories of Van Zant from the University of
Kentucky? In a few words, he relates stem cells turnover to aging. It's
somewhat related to what you're saying.

I only remember this paper but I'm sure you can find more in Medline.
De Haan, G., and Van Zant, G. (1999). "Genetic analysis of hemopoietic cell
cycling in mice suggests its involvement in organismal life span." Faseb J

Smigrodzki, Rafal wrote:
>### I wonder if it would be possible to triturate some early embryos,
>isolate the angiogenic stem cells, and then simply inject into some very
>old persons. If the early stem cells are not too immunogenic, or if we
>could induce tolerance (e.g. by coinjection of antibodies against
>costimulatory molecules), this could very effectively prevent endovascular
>lesions, eliminating most stroke and heart disease.

Injecting embryonic cells in old persons is an old treatment but its
effects, apart from treatment in Parkinson's disease, are negligible. I
remember there was a Swiss clinic using the procedure as an overall
anti-aging method but they were swindlers.

Best wishes.

Joao Pedro de Magalhaes
The University of Namur (FUNDP)
Unit of Cellular Biochemistry & Biology (URBC)
Rue de Bruxelles, 61. B-5000 Namur. Belgium.

Fax: + 32 81 724135
Phone: + 32 81 724133
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