Life Span Extension

From: Smigrodzki, Rafal (SmigrodzkiR@MSX.UPMC.EDU)
Date: Fri Nov 09 2001 - 11:45:34 MST

Robert Bradbury wrote:

lifespan) or accumulated DNA damage in the stem cells causing
cell checkpoint blocks on division -- but in either case --
if you can isolate, increase the number of, and return
such cells to their natural reservoirs you will likely
have a fairly effective anti-aging therapy.

Interestingly enough it will not require technology that
is much beyond that we currently have available.

### I wonder if it would be possible to triturate some early embryos,
isolate the angiogenic stem cells, and then simply inject into some very old
persons. If the early stem cells are not too immunogenic, or if we could
induce tolerance (e.g. by coinjection of antibodies against costimulatory
molecules), this could very effectively prevent endovascular lesions,
eliminating most stroke and heart disease.

Rafal Smigrodzki, MD-PhD

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