On Fri, May 04, 2001 at 06:56:00PM -0700, Mark Plus wrote:
> Transhuman Mailing List
>
> From:
>
> http://news.bbc.co.uk/hi/english/sci/tech/newsid_1312000/1312708.stm
>
> Friday, 4 May, 2001, 15:26 GMT 16:26 UK
> Genetically altered babies born
The original paper is
Jason A. Barritt,1, Carol A. Brenner, Henry E. Malter and Jacques Cohen,
Mitochondria in human offspring derived from ooplasmic transplantation:
Brief communication, Human Reproduction, Vol. 16, No. 3, 513-516, March
2001
Abstract
Ooplasmic transfer from fertile donor oocytes into potentially
compromised recipient patient oocytes has led to the birth of nearly 30
babies worldwide. Cytoplasmic transplantation has caused apprehension,
since the mixing of human ooplasm from two different maternal sources
may generate mitochondrial (mt) heteroplasmy (both recipient and donor
mtDNA) in offspring. This investigation traced the mitochondrial donor
population both during the ooplasmic transfer technique and in the
bloods of two 1 year old children using mtDNA fingerprinting. Donor
ooplasm stained for active mitochondria was transferred into recipient
ooplasm and the mitochondria were visualized by confocal microscopy
after the microinjection procedure and fertilization. Heteroplasmy was
found in the blood from each of the children. This report is the first
case of human germline genetic modification resulting in normal healthy
children.
If you have access, it can be found at
http://humrep.oupjournals.org/cgi/content/full/16/3/513?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&titleabstract=mitochondria&searchid=QID_NOT_SET&stored_search=&FIRSTINDEX=&journalcode=humrep
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