From: Joao Magalhaes (jpnitya@sapo.pt)
Date: Wed Jul 02 2003 - 16:38:25 MDT
First of all, mutants in mice affecting the IGF, IGF-related, or similar
hormonal pathways--e.g. growth hormone--increase longevity a maximum of
50%, not the two-fold differences seen in worms. Secondly, mice with these
hormone disruptive mutations have delayed growth and many are dwarfs--one
strain is even called Ames dwarf mice. Therefore, they are not normal mice.
For me, the greatest interest in this paper is that it shows how it is
possible to have key genes regulating aging--something evolutionary
biologists thought impossible--and acting upstream of the aging process.
Obviously that the challenge now is finding these genes in mammals and then
tweaking the human aging process.
At 17:22 02-07-2003 -0500, you wrote:
>"urn:schemas-microsoft-com:office:office" xmlns:w =
>"urn:schemas-microsoft-com:office:word">
>Here's an article that I thought would be interesting to everyone. It
>concerns some genes that make roundworms and mice live twice as long, and
>healthier, when altered.
>
>
><http://www.spacedaily.com/news/life-03ze.html>http://www.spacedaily.com/ne
ws/life-03ze.html
>
Joao Magalhaes (joao.magalhaes@fundp.ac.be)
Website on Aging: http://www.senescence.info
Reason's Triumph: http://www.jpreason.com
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