From: Emlyn O'regan (oregan.emlyn@healthsolve.com.au)
Date: Thu May 08 2003 - 20:59:03 MDT
As far as I remember, the source is:
\shared\groups\it\shared\GasData\dev\curr
You want everything in there. The source is in the source folders, the
packages folder contains the package files for creating installable
packages, bin contains the latest compiled binaries, and bincompat contains
the binary compatibility binaries. Note that the binary compatibility
binaries should be treated as part of the source; they define how the
components of GasData talk to each other. You will have incredible trouble
updating GasData without the binary compatibility files being available
during the vb compilation process!
Emlyn
> -----Original Message-----
> From: Greg Burch [mailto:gregburch@gregburch.net]
> Sent: Friday, 9 May 2003 10:34 AM
> To: extropians@extropy.org
> Subject: MED/BIO: Get a Cold, Kill Cancer
>
>
> This seems Really Important -- is it?
>
> http://www.chron.com/cs/CDA/ssistory.mpl/metropolitan/1899204
>
> May 7, 2003, 9:36AM
>
> Cold virus outsmarts, destroys brain tumors
> Genetically engineered cells target only cancers
> M.D. Anderson plans clinical trials for next year
> By TODD ACKERMAN
> Copyright 2003 Houston Chronicle Medical Writer
> RESOURCES
> . Graphic: Virus kills brain tumors
>
> Local scientists have turned a cold virus into a kind of "smart bomb"
> that may be able to destroy the deadliest form of brain cancer.
>
> In experiments with mice, University of Texas M.D. Anderson Cancer
> Center researchers are reporting that a genetically engineered version
> of the common cold infected and killed malignant glioma cells that
> resist other therapy. The virus doesn't harm normal tissue.
>
> "Viral therapy like this may be just what we need to treat a complex
> disease like cancer," said Dr. Frederick Lang, a professor of
> neurosurgery and primary investigator of the study. "Cancer can be
> devious the way it does everything possible to avoid destruction, but
> viruses are equally tricky and may be able to outsmart brain tumors."
>
> In today's issue of the Journal of the National Cancer Institute, M.D.
> Anderson researchers said the therapy produced a response on
> glioma not
> previously seen with any other treatment. Clinical trials with people
> are expected to begin late next year.
>
> Roughly 17,000 new cases of brain tumors are diagnosed in the United
> States every year and half are gliomas, a primary type which
> arises from
> the brain itself rather than metastasizing from another location.
> Surgery, radiation therapy, steroids and chemotherapy can prolong
> survival, but most everyone dies within a year.
>
> The virus is designed in such a way that to reproduce itself, it can
> only replicate in cancer cells, not healthy tissue. While reproducing,
> it kills cancer cells, and when no more are left to infect, the virus
> simply dies.
>
> The idea of using viruses to kill cancer cells has been
> around since the
> 1950s, but it is only in recent years that it is moving toward
> application. Therapeutic viruses for lung cancer and head and neck
> cancer are in clinical trials, said Howard Fine, director of the brain
> tumor program at the National Cancer Institute.
>
> The NCI is providing $1 million to produce the drug-grade
> version of the
> therapy in its laboratories. It is scheduled to be finished in time to
> start enrolling patients in a study in the winter of 2004.
>
> But Fine warned against expecting too much from the therapy. He called
> it "a promising approach that is one of many good ideas out
> there," but
> said success in animal models is a long way from success in human
> patients. He said it is unclear whether the virus will
> replicate as well
> in humans, where glioma cells are surrounded by normal cells; in mice,
> glioma cells cluster together.
>
> But the results in the mice were extraordinary. The virus cured 60
> percent of the glioma tumors implanted in mice brains whereas
> mice given
> a placebo died after less than three weeks. (A precursor of the virus
> cured 15 percent of the tumors.)
>
> The mice that survived treatment with the experimental virus
> were killed
> for examination. Researchers found only empty cavities and scar tissue
> where the tumors once were.
>
> "This therapy needs more study, but it has a lot of
> potential," said Dr.
> Juan Fueyo, a professor in M.D. Anderson's department of
> neuro-oncology,
> the study's lead author and the developer of the genetically
> engineered
> adenovirus. "We've never had this kind of result with any kind of
> treatment on glioma -- in humans or animals."
>
> The virus is injected directly into the brain tumor
> surgically, through
> a small hole. Lang expressed hope the therapy might work even
> better in
> humans because delivery would be more precise.
>
> Researchers are studying human adenoviruses for a wide range
> of medical
> uses, from cancer therapy to gene therapy, because they are so good at
> infecting human cells. One question is how the immune system will
> respond -- will it overreact and cause illness or kill the virus, or
> will it be boosted to kill the cancer or other pathogen.
>
> But Lang said he's optimistic the treatment will accomplish its goal
> before the immune system goes after it.
>
> The research team also included scientists from the University of
> Alabama at Birmingham and the Institut Catala d'Oncologia in
> Barcelona,
> Spain.
>
>
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