From: Adrian Tymes (wingcat@pacbell.net)
Date: Sat Apr 26 2003 - 10:28:17 MDT
--- "Robert J. Bradbury" <bradbury@aeiveos.com> wrote:
>
http://www.sciencemag.org/cgi/content/abstract/300/5619/636
>
> I don't have access to Science otherwise I'd post
> the abstract.
> It also doesn't appear to have made it into PubMed
> yet...
Happy to oblige.
Alpha-synuclein ({alpha}-syn) and tau polymerize into
amyloid fibrils and form intraneuronal filamentous
inclusions characteristic of neurodegenerative
diseases. We demonstrate that {alpha}-syn induces
fibrillization of tau and that coincubation of tau and
{alpha}-syn synergistically promotes fibrillization of
both proteins. The in vivo relevance of these findings
is grounded in the co-occurrence of {alpha}-syn and
tau filamentous amyloid inclusions in humans, in
single transgenic mice that express A53T human
{alpha}-syn in neurons, and in oligodendrocytes of
bigenic mice that express wild-type human {alpha}-syn
plus P301L mutant tau. This suggests that interactions
between {alpha}-syn and tau can promote their
fibrillization and drive the formation of pathological
inclusions in human neurodegenerative diseases.
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