RE: Allotopic expression and other fun stuff was RE: specific amino acid restriction does the same thing as calorie restriction?

From: Rafal Smigrodzki (rafal@smigrodzki.org)
Date: Tue Apr 22 2003 - 19:23:46 MDT

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    Robert wrote:

    >
    > So one could design an additional chromosome based on EBV where
    > all (most?) of the EBV genes are replaced with recoded mito genes.
    > Then one extracts the most primitive stem cells one can find
    > in the body, infects them with the anti-aging EBV-based therapy
    > vector then amplifies the # you have and puts the modified stem
    > cells back into the body.
    >
    ### No need to - two groups have recently developed methods of transfecting
    full-length mito genomes into mitos, so you can go there directly.

    One of these guys was rejected by a prominent journal after showing
    *mitochondria glowing with GFP* transcribed from the mtDNA! The reviewer
    reportedly simply commented on the photographs "This can't be true".
    Un-****ing-believable.

    But anyway, it is indeed possible to replace full length mtDNA now, so it's
    just a matter of time before somebody manages to do something useful with
    it.

    Rafal

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