Re: specific amino acid restriction does the same thing as calorie restriction?

From: Rafal Smigrodzki (rafal@smigrodzki.org)
Date: Sun Apr 20 2003 - 11:13:41 MDT

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    ----- Original Message -----
    From: "Robert J. Bradbury" <bradbury@aeiveos.com>
    To: <extropians@extropy.org>
    Sent: Sunday, April 20, 2003 11:47 AM
    Subject: RE: specific amino acid restriction does the same thing as calorie
    restriction?

    >
    >
    > On Sat, 19 Apr 2003, Reason wrote:
    >
    > > a) the gene-and-protein-expression-tinkerers have figured out a
    pill/therapy
    > > that does the same thing as CR.
    >
    > This is going to be *very* tricky -- you have to tell most of cells
    > in the body to enter a CR state but you have to tell the appetite
    > sensing mechanisms in the brain that you *aren't* CR.

    ### That may be not so difficult after all. Recent discoveries of
    melanocortins, peptide YY, agouti-related peptide, leptin, ghrelin, and
    orexins give a lot of targets for the pill designer, targets which should
    allow suppression of appetite, but at the same time targets that are present
    only in very small numbers of hypothalamic neurons. It will be probably
    easier to design true CR regimens without hunger, rather than make-believe
    CR (full caloric intake with CR-like physiology in most cells), but one way
    or another it should become possible to uncouple the feeling of satiety from
    actual energy levels in the body.

    Rafal

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