manganese SOD and CR

From: Rafal Smigrodzki (rafal@smigrodzki.org)
Date: Fri Apr 04 2003 - 09:11:32 MST

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    Here is a reference that just landed in my inbox:

     Chem Biol 2003 Mar;10(3):197-8
         
        Life extension properties of superoxide dismutase mimics arise from
    "Calorie Restriction".

        Naughton DP, Fisher AE.

        School of Pharmacy and Biomolecular Science, University of Brighton,
    Lewes Road, BN2 4GJ, Brighton, United Kingdom

        Manganese-salen superoxide dismutase mimics interfere with the
    mitochondrial electron transport chain by acting as antimetabolites and
    thus effect "calorie restriction," leading to extended lifespan.

    ### Unfortunately, the article is currently not available online. If the
    above is true, the SOD mimics could be of some importance in life
    extension, after all.

    Rafal

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