From: Anders Sandberg (asa@nada.kth.se)
Date: Mon Feb 17 2003 - 05:05:20 MST
On Mon, Feb 17, 2003 at 09:05:30PM +1100, avatar wrote:
> Does anyone know whether any research has been done indicating what
> area of dna is responsible for producing telomerase and for producing
> repair mechanisms for telomerase in somatic cells.
In the nature paper of Sun-Hee Leem et al, they mention chromosome 5:
http://216.239.33.100/search?q=cache:DsRz-yBTtm4C:www.nature.com/cgi-taf/DynaPage.taf%3Ffile%3D/onc/journal/v21/n5/full/1205122a.html+telomerase+gene+location&hl=en&ie=UTF-8
Here is a more detailled location:
http://www.rzpd.de/cgi-bin/cards/carddisp?TERT
> Can laser scissors
> and tweezers be used to cut and paste this dna in non-somatic cells?
It is already there, it is just not expressed. I would probably go for
activating the promoter region instead, which would make the cell
express telomerase.
Laser scissors and tweezers are likely too blunt for this kind of
manipulation unless you bind some microspheres to the right section
(cover the microspheres with the right sequence and have them stick,
then you can move the gene around).
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