RE: Performance enhancement with selegiline

From: gts (gts_2000@yahoo.com)
Date: Thu Feb 13 2003 - 13:32:03 MST

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    Rafal wrote:

    > ### The study provides evidence that rats on selegiline live longer.

    Yes it certainly does.

    > Whether the same applies to humans, is a matter of conjecture, which
    > is why I agree with your use of "may", as in "maybe yes, maybe not".

    Yes, and that is why I am careful to use the word "may."

    For similar reasons, I think you and I may be mammals similar to these

    ...rats, hampsters, mice, and dogs...

    all of whose lives were extended by selegiline treatment.

    (Here is yet *another* abstract about the neuroprotective/life-extending
    benefits of selegiline)

    ABSTRACT
    Assessing the effects of deprenyl on longevity
    and antioxidant defenses in different animal models

    Kitani K, Kanai S, Ivy GO, Carrillo MC

    National Institute for Longevity Sciences,
    Aichi, Japan.
    Ann N Y Acad Sci 1998 Nov 20; 854:291-306
    Among many pharmaceuticals that have been tested for their effects on
    longevities of different animal rodents, deprenyl is unique in that its
    effects on longevity has been tested in at least four different animal
    species by independent research groups and that the effect has been
    postulated to be due to its effect of raising such antioxidant enzyme
    activities as superoxide dismutase (SOD) and catalase (CAT) in selective
    brain regions. Thus far, in all four species of animals examined (rats,
    mice, hamsters, and dogs), a positive effect was demonstrated, although
    the extent of its effect is quite variable. Our group has examined the
    effect on longevities in rats and mice and on antioxidant enzymes in
    rats, mice, and dogs. Although in rats of both sexes, we have obtained
    positive effects on longevity, two studies with different doses in mice
    did not reveal a significantly positive effect. We have observed,
    however, significantly positive effects on SOD (in Cu, Zn-, and Mn-) as
    well as CAT (but not glutathione peroxidase) activities in the brain
    dopaminergic system such as in the S. nigra and striatum (but not in
    hippocampus) in all rats, mice, and dogs, although the effects were
    quite variable, depending on the doses used. In mice, however, a
    long-term administration (3x/w, 3 months) caused a remarkable decrease
    in the magnitude of activity as well as a narrowing of the effective
    dose range, which may explain a relatively weak effect of the drug on
    mouse longevity. Further, a recent study on aging beagle dogs by Ruehl
    et al. showed a remarkable effect on longevity, which agrees with our
    SOD study in dogs. Although deprenyl has been claimed to have several
    other effects, such as a radical scavenging effect and a neuroprotective
    effect, past reports on its effects on longevities and antioxidant
    defenses are compatible with the notion that the drug prolongs the life
    span of animals by reducing the oxidative damage to the brain
    dopaminergic system during aging. Further, our studies on F-344 rats as
    well as a dog study by Ruehl et al. suggest that the drug may at least
    partially prolong the life span of animals by enhancing immune system
    function and preventing tumor development in animals.



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