From: R. Coyote (coyyote@hotmail.com)
Date: Sun Feb 09 2003 - 12:15:18 MST
This might be useful information
Phenolic anti-inflammatory antioxidant reversal of
Abeta-induced cognitive deficits and neuropathology
by
Frautschy SA, Hu W, Kim P, Miller SA,
Chu T, Harris-White ME, Cole GM.
VAGLAHS-Sepulveda GRECC,
Departments of Medicine and Neurology,
UCLA, 16111 Plummer Street,
North Hills, CA, USA Neurobiol Aging 2001 Nov;22(6):993-1005
ABSTRACT
Both oxidative damage and inflammation have been implicated in age-related
neurodegenerative diseases including Alzheimer's Disease (AD). The yellow
curry spice, curcumin, has both antioxidant and anti-inflammatory activities
which confer significant protection against neurotoxic and genotoxic agents.
We used 22 month Sprague-Dawley (SD) rats to compare the effects of the
conventional NSAID, ibuprofen, and curcumin for their ability to protect
against amyloid beta-protein (Abeta)-induced damage. Lipoprotein
carrier-mediated, intracerebroventricular infusion of Abeta peptides induced
oxidative damage, synaptophysin loss, a microglial response and widespread
Abeta deposits. Dietary curcumin (2000 ppm), but not ibuprofen, suppressed
oxidative damage (isoprostane levels) and synaptophysin loss. Both ibuprofen
and curcumin reduced microgliosis in cortical layers, but curcumin increased
microglial labeling within and adjacent to Abeta-ir deposits. In a second
group of middle-aged female SD rats, 500 ppm dietary curcumin prevented
Abeta-infusion induced spatial memory deficits in the Morris Water Maze and
post-synaptic density (PSD)-95 loss and reduced Abeta deposits. Because of
its low side-effect profile and long history of safe use, curcumin may find
clinical application for AD prevention.
Piracetam
----- Original Message -----
From: "Rafal Smigrodzki" <rms2g@virginia.edu>
To: <extropians@extropy.org>
Sent: Saturday, February 08, 2003 5:23 PM
Subject: Re: Performance enhancement with selegiline
>
> ----- Original Message -----
> From: "Alex Ramonsky" <alex@ramonsky.com>
> To: <extropians@extropy.org>
> Sent: Saturday, February 08, 2003 6:30 AM
> Subject: Re: Performance enhancement with selegiline
>
>
> > Gentlemen;
> > I do not know if this is relevant to your discussion, and please forgive
> > me for butting in, but...
> >
> > ...'Geddy' has been taking Selegiline (R-(-)-Deprenyl hydrochloride) @
> > 20mg daily since 21st December 2002. Geddy is a 44-year-old male human
> > in average health who does not suffer from any neurological disorder,
> > and is basically taking selegiline to see what happens.
> > We are monitoring him. He intends to stay on the drug indefinitely
> > unless there are deleterious effects.
> > For obvious reasons Geddy wishes to remain low-profile! We're happy to
> > discuss this trial and any clinical results if contacted WITH PGP at
> > alex@ramonsky.com
> > He is however happy for the world to know the following:
> > He has noticed several changes since beginning the trial. The first
> > change was an increase in confidence, he felt calmer and less shy and
> > was able to communicate more easily. He felt more confident and
> > assertive in business environments. Then he noticed that an annoying
> > nervous habit of wiggling his toes had stopped. He feels he can control
> > his emotions more sensibly and think more rationally under stress.
> > His dreams have become more vivid, and he feels his fantasy life and
> > imagination have improved. He explains an odd sensation of 'thinking too
> > fast to be able to verbalise it', which is the only downer so far. On
> > the whole he seems a great deal happier as an individual.
> > We may have to wait some time to see if he lives longer, of course. But
> > other data are coming in, all along the way. As far as I know, this is
> > the first trial of a healthy human?
> > : )
> > AR
>
> ### If he's happy with it, more power to him. It is not proven that
> selegiline will make you live longer, but then it won't cut your life
short,
> either. As long as it makes the user lead a happy, useful life, it's good.
>
> Rafal
>
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