From: gts (gts_2000@yahoo.com)
Date: Sat Feb 08 2003 - 04:47:47 MST
Here is more evidence of neuroprotection by selegiline/deprenyl:
This is evidence that selegiline protects neurons from death due to from
temporary lack of oxygen (hypoxia) as in stroke (ischemia).
ABSTRACT
L-deprenyl reduces brain damage in rats exposed to transient
hypoxia-ischemia.
Stroke 1995 Oct;26(10):1883-7 (ISSN: 0039-2499)
Knollema S; Aukema W; Hom H; Korf J; ter Horst GJ
University of Groningen, Department of Biological Psychiatry, The
Netherlands.
BACKGROUND AND PURPOSE: L-Deprenyl (Selegiline) protects animal brains
against toxic substances such as 1-methyl-1,2,3,6-tetrahydropyridine and
6-hydroxydopamine. Experiments were conducted to test whether L-deprenyl
prevents or reduces cerebral damage in a transient hypoxia/ischemia rat
model. METHODS: Rats were treated for 14 days with 2 mg/kg and 10 mg/kg
L-deprenyl or saline. After surgery a 20-minute hypoxia/ischemia period was
induced by simultaneous occlusion of the left common carotid artery and
reduction of the percentage of oxygen in the gas mixture to 10%. Rats were
killed 24 hours later. Silver staining was used to reveal damage in several
brain regions. RESULTS: In the brain, both L-deprenyl dosages reduced damage
up to 78% compared with the controls. Total brain damage was decreased from
23%-31% to 5%-9% with the L-deprenyl treatment (2 mg/kg: F1.13 = 6.956, P <
.05; 10 mg/kg: F1.13 = 5.731, P < .05). In the striatum, significant
treatment effects were found between both the L-deprenyl groups (2 mg/kg and
10 mg/kg, respectively) and the saline group (F1.13 = 14.870, P < .005; and
F1.13 = 8.937, P = .01; respectively). In the thalamus, significant
treatment effects were seen in the 2-mg/kg L-deprenyl group (F1.13 = 11.638,
P < .005) and the 10-mg/kg group (F1.13 = 8.347, P < .05) compared with the
control group. No significant damage decrease was seen in the hippocampus
and the cortex. CONCLUSIONS: The results show that L-deprenyl is effective
as a prophylactic treatment for brain tissue when it is administered before
hypoxia/ischemia. Mechanisms responsible for the observed protection remain
unclear. The regional differences in damage, however, are in accordance with
the reported regional increase in superoxide dismutase and catalase
activities after L-deprenyl treatment, suggesting the involvement of free
radicals and scavenger enzymes.
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