From: gts (gts_2000@yahoo.com)
Date: Fri Feb 07 2003 - 07:53:37 MST
In this classic research below by Joseph Knoll, lab rats were treated daily
for life with selegiline (deprenyl) and compared to a control group treated
with saline water.
The treated rats:
1) had better life-long sexual performance (measured probably by total
mounts and total ejaculations, as in other such studies)
2) had better learning performance (measured probably with the standard
sorts of mazes with which we humans like to aggravate lab rats), and
3) had prolonged life-spans.
In other words the selegiline (deprenyl) treated rats they lived longer,
sexier, smarter lives. They were transvermins. :)
-gts
ABSTRACT:
Sexual performance and longevity.
Knoll J.
Department of Pharmacology,
Semmelweis University of Medicine,
Budapest, Hungary
Exp Gerontol 1997 Jul;32(4-5):539-552
ABSTRACT
Sexually inactive ("low-performing," LP) and highly active
("high-performing," HP) rats were selected from a sexually inexperienced
population. Saline control LP rats (n = 44) lived 134.58 2.29 weeks, their
HP peers (n = 49) lived 151.24 1.36 weeks. Life-long treatment with 0.25
mg/kg (-)deprenyl, a selective inhibitor of MAO-B that also stimulates
action potential-transmitter release coupling in the catecholaminergic
neurons in the brain (catecholaminergic activity enhancer, CAE, effect),
enhanced the sexual and learning performance of both LP and HP rats and
prolonged their life. LP rats (n = 48) treated with (-)deprenyl lived 152.54
1.36 weeks and HP rats on (-)deprenyl (n = 50) lived 185.30 1.96 weeks. As
an indicator of the basic activity of catecholaminergic neurons, the resting
release of dopamine from the striatum, substantia nigra, and tuberculum
olfactorium, and of norepinephrine from the locus coeruleus, was measured in
2-, 4-, 8-, 16-, and 32-week-old male and female rats. The release of
transmitters between weaning and the second month of age, i.e., during the
crucial developmental phase of life, was significantly higher than either
before or after that period, indicating that a CAE mechanism starts working
with high intensity after weaning, lasts until the completion of full scale
sexual development, and shows an unparalleled decay thereafter. It was
concluded that the CAE regulation in the brain, stimulated by (-)deprenyl,
controls general activity and consequently the longevity of rats.
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