From: Joao Magalhaes (joao.magalhaes@fundp.ac.be)
Date: Thu Jan 23 2003 - 07:52:43 MST
Hi!
Some of you might have seen this but, here it goes:
Gorbunova V, Seluanov A, Pereira-Smith OM
Evidence that high telomerase activity may induce a senescent-like growth
arrest in human fibroblasts.
J Biol Chem. 2002 Dec 19 [epub ahead of print]
Basically, this work suggests that excessive telomerase activity may
actually cause a senescence-like phenotype. One possible explanations is
that, since telomerase is associated with cancer, cells have a mechanism to
induce senescence when telomerase levels are very high as an anti-cancer
protection. It makes sense that a cell with high levels of telomerase is a
potential danger and has to be stopped from proliferating.
You can get a reprint at: http://www.jbc.org/cgi/reprint/M212944200v1
All the best.
Joao Pedro de Magalhaes
The University of Namur (FUNDP)
Research Unit on Cellular Biology (URBC)
Rue de Bruxelles, 61. B-5000 Namur. Belgium.
Fax: + 32 81 724135
Phone: + 32 81 724133
Website on Aging: http://www.senescence.info
Reason's Triumph: http://www.jpreason.com
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