AGING: ... and Cancer... DKC1: an unusual player

From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Tue Jan 14 2003 - 16:53:51 MST


Science Daily is carrying some summary notes about work from
Memorial Sloan-Kettering on the DKC1 gene which appears to
play a role in both cancer and aging. Interestingly mutations
in this gene cause a disruption in ribosome function. That raises
some really interesting questions as to why the defects lead to
cancer and/or premature aging and not a host of other diseases.

See:
Mutation In DKC1 Gene Can Cause Rare Aging Disease And Cancer
http://www.sciencedaily.com/releases/2003/01/030114072906.htm

IMO, this raises the question of whether DKC1 causes decreased
accuracy an ribosome translation of mRNA into proteins and a
general result of decreased translation accuracy is cancer and/or
aging.

Robert



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