From: Joao Magalhaes (joao.magalhaes@fundp.ac.be)
Date: Tue Jan 14 2003 - 03:42:00 MST
Not exactly revolutionary. I mean, there's been other mice KO experiences
with IGF-1 and growth hormone to yield increases in lifespan. As for this
experiment, the most interesting part is the fact that the mice do not
develop dwarfism. Yet, IMHO, the most impressive and innovative lifespan
extension in mice remains the p66 experiment.
At 15:51 13-01-2003 -0800, you wrote:
>Looks like they have a concrete model for lifespan extension
>in mammals (F: 33% / M: 16%) in partial IGF-1R knockout mice.
>
>See:
>Cost-free longevity in mice
>Nature 421:125-126
>http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v421/n6919/full/421125a_fs.html&content_filetype=pdf
>
>and
>
>IGF-1 receptor regulatses lifespan and resistance to
>oxidative stress in mice.
>Nature 421:182-187
>http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v421/n6919/full/nature01298_fs.html&content_filetype=pdf
>
>Robert
Joao Magalhaes (joao.magalhaes@fundp.ac.be)
Website on Aging: http://www.senescence.info
Reason's Triumph: http://www.jpreason.com
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