78'th update on fly longevity experiments

From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Sat Jan 11 2003 - 12:02:11 MST


    This is the 78'th update of my fly longevity experiments. Average
temperature was 24.8 C during this run. Here I take yet another look at
combinations of acetyl-L-cysteine (ALC), and some antioxidants.
    CDP choline and citrulline both turned out to be a duds this time, and
ginkgo was toxic. As before, nicotinamide at a high dose was again toxic,
possibly because of inhibition of SIR2. Lipoic acid at the 100 mg dose
appeared to be ineffective this time, but the 200 mg dose was slightly
beneficial. Surprisingly the 400 mg dose was either toxic this time, or
very unlucky. Overall there is not much of interest here.
    Next run, I look away from ALC, investigate some novel supplements,
and obtain some intriguing results.

Run #78 Percent Survival on Day
supplement 4 11 16 23 29 34 40 46 51 56
_______________________________________________________________
control 96 75 63 58 58 42 13 4 0 -
ALC 125 mg + CDP choline 500 mg 92 56 52 52 44 24 20 8 0 -
ALC 125 mg + citrulline 1/2 tsp 95 52 48 38 38 33 19 5 0 -
ALC 125 mg + ginkgo 20 mg 52 43 30 17 17 17 9 0 - -
ALC 125 mg + ginkgo 80 mg 63 38 0 - - - - - - -
ALC 125 mg + lipoic 100 mg 100 73 73 53 53 40 13 0 - -
ALC 125 mg + nicotinamide 94 mg 100 67 61 44 44 28 11 6 6 0
ALC 125 mg + nicotinamide 375 mg 57 21 14 7 7 0 - - - -
carnitine + lipoic 100 mg 95 60 60 55 50 20 15 10 0 -
lipoic 100 mg 89 58 53 42 32 11 5 0 - -
lipoic 200 mg 96 83 70 61 61 35 22 9 4 0
lipoic 400 mg 100 19 19 13 0 - - - - -



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