Adult Stem Cells: critical insight

From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Thu Jan 09 2003 - 13:25:58 MST


Scientists at MIT seem to have confirmed a critical aspect
of the architecture of adult stem cells (something I was
unaware of).

It seems that adult stem cells have a means of selective
chromosome segregation such that the daughter cells get
the all of the newly replicated DNA, while the adult
stem cell retains all of the original DNA.

See:
MIT research helps find elusive adult stem cells
http://web.mit.edu/newsoffice/nr/2002/stemcells.html

Merok JR, Lansita JA, Tunstead JR, Sherley JL.
Cosegregation of chromosomes containing immortal DNA
strands in cells that cycle with asymmetric stem cell kinetics.
Cancer Res. 2002 Dec 1;62(23):6791-5.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12460886&dopt=Abstract

Also relevant seems to be:
Proc Natl Acad Sci U S A 2002 Aug 6;99(16):10567-70
Somatic stem cells and the kinetics of mutagenesis and carcinogenesis.
Cairns J.
http://www.ncbi.nlm.nih.gov:80/entrez/utils/fref.fcgi?http://www.pnas.org/cgi/pmidlookup?view=full&pmid=12149477

and
Nature 1975 May 15;255(5505):197-200
Mutation selection and the natural history of cancer.
Cairns J.
(no abstract available)

R.



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