(Please forgive me if this has been asked and answered previously. I have been lurking for a bit, but by no means am I familiar with everything that has been said and discussed.)
Concerning uploaded individuals. Considering that such a being would, presumably, be immortal, and considering that such a being would wish to retain all of its memories (and probably with more clarity than is afforded by our protein brains, which are notorious for storing memories in a somewhat fuzzy and incomplete manner), there would seem to be some concern about space. Certainly my computer could not hold even a significant fraction of my memories. Now, admittedly, my brain is comparatively small, and seems to do alright, but most, if not all, of us have witnessed the loss of memories which tends to occur in the later years of a person's life, which results partially from the fact that there is a limited space capacity for memories. One would want to retain all memories, and therefore would want upgrades, spare hard drives, if you will. Is this a concern? Is it realistic to expect resources to hold out? How many people are expected to ultimately be uploaded?