On Thu, Dec 13, 2001 at 08:19:52PM -0800, J. R. Molloy wrote:
> Bartke's group wanted to know why Ames dwarf mice, whose dwarfism is caused by
> a mutation in just one gene, also live longer than their normal siblings. Both
> caloric restriction and the dwarfism mutation increased the prolonged
> healthspan in mice from an average of two years to an average of three, Bartke
> says. "If you put it in terms of human life, if the average lifespan in the
> human in industrial society is somewhere around 75, an increase of 50 percent
> would bring you to somewhere around 110 to 115."
Though the interesting thing is that dwarf mice on CR lived even
longer than CR-only or dwarf-only mice, indicating at least somewhat
independent mechanisms. The graph seems to indicate that the dwarf
mice' genentic makeup delays aging, while CR decelerates aging.
Actually, the paper in Nature apparently says as much. See
http://groups.yahoo.com/group/crsociety/message/15565 for an
analysis by Michael Rae on the CRSociety list.
-- Mike Linksvayer http://gondwanaland.com/ml/
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