Re: NEWS: Fugo genome draft complete

Date: Thu Oct 25 2001 - 18:58:37 MDT

In a message dated 10/25/01 4:23:15 PM, writes:

>Having the human & Fugu genomes
>largely complete and the Mouse and Rat in progress will
>accelerate comparative genomics. That will allow a
>more rapid construction of the complete picture of
>what genes regulate what other genes because regulatory
>regions will be conserved across genomes and allow computerized
>comparisons to identify them (rather than messy wet lab
>experiments that are now required).

Yes and no. Protein and RNA regulatory regions are well-conserved,
but DNA regulatory regions are quite labile and won't be recognizable
between humans and pufferfish. Unfortunately quantitative genetics
is suggesting non-coding regions are the main source of variation
for evolutionary change, and the default assumption is that most
acts through DNA sequences. Most of it *has* to, as it's in
nontranscribed regions, although there's a significant amount
of stuff in transcribed regions which might be RNA (and thus
more conserved) regulation.

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