In a message dated 10/25/01 4:23:15 PM, bradbury@aeiveos.com writes:
>Having the human & Fugu genomes
>largely complete and the Mouse and Rat in progress will
>accelerate comparative genomics. That will allow a
>more rapid construction of the complete picture of
>what genes regulate what other genes because regulatory
>regions will be conserved across genomes and allow computerized
>comparisons to identify them (rather than messy wet lab
>experiments that are now required).
Yes and no. Protein and RNA regulatory regions are well-conserved,
but DNA regulatory regions are quite labile and won't be recognizable
between humans and pufferfish. Unfortunately quantitative genetics
is suggesting non-coding regions are the main source of variation
for evolutionary change, and the default assumption is that most
acts through DNA sequences. Most of it *has* to, as it's in
nontranscribed regions, although there's a significant amount
of stuff in transcribed regions which might be RNA (and thus
more conserved) regulation.
This archive was generated by hypermail 2b30 : Sat May 11 2002 - 17:44:16 MDT