Title
Evaluation of butylated
hydroxyanisole, myo-inositol, curcumin, esculetin,
resveratrol and lycopene as inhibitors of benzo[a]pyrene plus
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in
A/J mice.
Source
Cancer Letters. 137(2):123-30, 1999 Apr 1.
Abstract
The potential activities of butylated
hydroxyanisole (BHA), myo-inositol, curcumin, esculetin,
resveratrol and lycopene-enriched tomato oleoresin (LTO) as chemopreventive
agents against lung tumor induction in A/J mice by the tobacco smoke
carcinogens benzo[a]pyrene (BaP) and
4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were evaluated. Groups
of 20 A/J mice were treated weekly by gavage with a mixture of BaP and NNK (3
micromol each) for 8 weeks, then sacrificed 26 weeks after the first
carcinogen treatment. Mice treated with BHA (20 or 40 micromol) by gavage 2 h
before each dose of BaP and NNK had significantly reduced lung tumor
multiplicity. Treatment with BHA (20 or 40 micromol) by gavage weekly or with
dietary BHA (2000 ppm), curcumin (2000 ppm) or resveratrol (500 ppm) from 1
week after carcinogen treatment until termination had no effect on lung tumor
multiplicity. Treatment with dietary myo-inositol (30,000 ppm) or esculetin
(2000 ppm) from 1 week after carcinogen treatment until termination
significantly reduced lung tumor multiplicity, with the effect of
myo-inositol being significantly greater than that of esculetin. Treatment
with dietary LTO (167, 1667 or 8333 ppm) from 1 week before carcinogen
treatment until termination had no effect on lung tumor multiplicity. The
results of this study demonstrate that BHA is an effective inhibitor of BaP
plus NNK-induced lung tumorigenesis in A/J mice when administered during the
period of carcinogen treatment and that, among the compounds tested,
myo-inositol is most effective after carcinogen treatment.
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