extropians: BMI and mortality in the aged

BMI and mortality in the aged

Doug Skrecky (oberon@vcn.bc.ca)
Wed, 25 Aug 1999 05:02:54 -0700 (PDT)

Chubby old people seem to do well in the longevity sweapstakes. This seems to fit in with other research which associates risk factors such as low cardioresipratory fitness, and high blood pressure as being responsible for higher mortality in young people at either end of the BMI scale. These would tend to die early, yielding mostly survivors that are relatively healthy regardless of BMI.
The "U" or "J" relation found in most studies relating human mortality with body weight, thus tends to naturally flatten out at progressively older ages.

Allison DB. Gallagher D. Heo M. Pi-Sunyer FX. Heymsfield SB. Institution
Obesity Research Center, St. Luke's/Roosevelt Hospital Center, Columbia University College of Physicians & Surgeons, NY 10025, USA. Title
Body mass index and
all-cause mortality among people age 70 and over: the Longitudinal Study of Aging.
International Journal of Obesity & Related Metabolic Disorders. 21(6):424-31, 1997 Jun.
OBJECTIVES: To assess the relationship between body mass index (BMI; kg/m2) and
mortality in a large nationally representative sample of US adults over age 70 years. DESIGN: Prospective longitudinal cohort study, the Longitudinal Study of Aging (LSOA). Subjects were all those 7260 black and white people (2769 men, 4491 women) initially interviewed in 1984 for whom height and weight were available. These subjects were followed through to

  1. MEASUREMENTS: Measurements included self-reported height and weight, date of death if subjects died, sex, age, race, measures of socio-economic status, number of living first degree relatives, and responses to questions asking whether the subject had retired due to poor health, had difficulty eating, worried about their health, and felt their health was worse than during the prior year. Smoking status was not assessed. RESULTS: When analyzed via Cox proportional hazard regression, the relationship between BMI and mortality, represented by means of hazard ratio, was clearly U-shaped for both men and women. The base of the curves was fairly wide suggesting that a broad range of BMIs are well tolerated by older adults. The minimum mortality (estimated from the fitted proportional hazard models) occurred at a BMI of approximately 31.7 for women and 28.8 for men. The results were essentially unchanged, if analyses were weighted, if various disease states were controlled for, and if apparently unhealthy subjects were excluded. CONCLUSIONS: The finding of the relatively high BMI (27-30 for men, 30-35 for women) associated with minimum hazard in persons older than seventy years supports some previously documented findings and opposes others and, if confirmed in future research, has implications for public health and clinical recommendations.