Eugene Leitl wrote:
> Freeman Craig Presson writes:
>
> > How much 1,4-butanediol is in each capsule? The www site does not say.
The
> > prices in bulk from Fluka look much more reasonable, but I can't
compare the
> > two without knowing what a dose is in mL.
>
> If you go to that infamous source ( http://www.lycaeum.org ) the
> suggested dosis seems to be 1..3 ml. I personally never go over 2
> ml. This seems to imply that the 250 ml Fluka bottle is good for
> 83..250 d.
>
Wait a minute. At the highest dosage of Fluka's product (3 ml = 83 doses =
~3 months worth) and at the Fluka price of $9.35 for 250 ml . . . that's a
little over $3.00/month compared to Somatopro's $40-$65 range. Even better,
2.5 L at $44.25 results in a monthly cost of ~ $1.50.
Can this be right?
I also found the following statement at
http://www.nutritionalsupplements.com/borametz.html and thought it should
be noted.
I did a lot of research on this topic a couple years back and I could probably find the abstracts on some of the toxicity studies. To give you an overview though, most of them found that there was no carcinogenity, genetic mutation, and the lethal dose number was relatively high (around 10 g/kg for mice). Unfortunately, 1,4-butanediol has been shown to cause substantial kidney damage and some liver damage. Most of the tests indicate that 200-300 mg/kg/per day over even a couple of days of dosing would cause damage. Doses below this were inconclusive except for one study where 2 out of 7 human patients given 1,4-butanediol by enema at only 30 mg/kg/per day died over the 2 week test period. The other 5 recovered with some permanent kidney damage. Studies have been done on humans, mice, rats, guinea pigs, and rabbits and almost every test that was done at 100 mg/kg or more per day resulted in kidney damage and liver damage. This is probably the reason that ASN pulled this and doesn't want to talk about it. - anonymous
[This followed up by:]
The National Toxicology Program did a study of the toxicology of 1,4 Butanediol and found that since it was rapidly converted into GHB in the body the results would be the same as GHB -- no toxicity. From what I've know, it is my belief that any kidney or liver problems caused by products containing BDO are because of the impurity of the BDO used. BDO is an industrial chemical used to make things like polyurethane bumpers for cars. It is very hard to find high purity BDO that is safe to consume, even harder than finding high purity butyrolactone. I have a 1,4-Butanediol product, NeuroMod, now available to researchers. I recommend the book "GHB -- A Natural Mood Enhancer" by Ward Dean, MD, Steve Fowkes, and John Morganthaller.
Paul Anacker, JD
Lead Editor of "Biological Aging Measurement"
So it sounds like Fluka is high grade and cheap as well. Do they restrict who the sell to (e.g. biochemists, researchers, etc.)
Scott