Authors
Lonnrot K. Holm P. Lagerstedt A. Huhtala H. Alho H.
Institution
Laboratory of Neurobiology, University of Tampere, Medical School, Finland.
Title
The effects of lifelong ubiquinone Q10 supplementation on
the Q9 and Q10 tissue concentrations and life span of male rats and mice.
Source
Biochemistry & Molecular Biology International. 44(4):727-37, 1998 Apr.
Abstract
The effect of lifelong oral supplementation with ubiquinone
Q10 (10 mg/kg/day) was examined in Sprague-Dawley rats and C57/B17 mice.
There were no significant differences in survival or life-span found in
either rats or mice. Histopathologic examination of different rat tissues
showed no differences between the groups. In Q10 supplemented rats, plasma
and liver Q10 levels were 2.6 to 8.4 times higher at all age points than in
control rats. Interestingly, in supplemented rats the Q9 levels also were
significantly higher (p<0.05) in plasma and liver at ages 18 and 24 months.
Neither Q9 nor Q10 levels were affected by supplementation in kidney, heart,
or brain tissues. In spite of the significant changes in plasma and liver
ubiquinone concentrations, lifelong Q10 supplementation did
not prolong or shorten the lifespan of either rats or mice.