LE: Life Extension Update 2001.07.20

From: Technotranscendence (neptune@mars.superlink.net)
Date: Fri Jul 20 2001 - 19:05:08 MDT



LIFE EXTENSION UPATE EXCLUSIVE: Personal choices add up to ten years to

WHAT'S HOT: Free radical fighter studied

PROTOCOL: Prevention

FEATURED PRODUCTS OF THE WEEK: Life Extension Mix, Chronoforte

Chat with Dr Andrew Baer live on Monday!

Personal choices add up to ten years to lifespan

The July 9 2001 issue of the journal Archives of Internal Medicine published
of the results of research that set out to prove that prevention, as
accomplished by diet, exercise and not smoking, effects lifespan. Although
this seems like a self-evident hypothesis, few longterm studies have
verified it.

The researchers enrolled 34,192 Seventh-Day Adventists in California in
1976, who were followed until 1988. Many Seventh-Day Adventists follow
vegetarian diets, are nonsmokers, and are perceived in general to have
healthier habits than most Americans. At the study's onset, participants
filled out a questionnaire in regard to their diet as well as exercise and
other habits. Subjects were contacted on a yearly basis and asked if they
had been hospitalized. The 5,193 deaths that occurred were verified by
state records.

Nearly one third of the participants were categorized as vegetarian, defined
as consuming meat less than once per month. None of the participants were
smokers. Forty percent indicated that they exercised vigorously for fifteen
minutes three times per week or more often. Over half of the women had used
hormone replacement therapy. The positive association between hormone
replacement and lifespan may be attributable to the fact that women who use
HRT are generally more health-conscious, as the only large clinical trial on
HRT did not show that it prevents heart disease as previously believed.

Survival of the study participants was compared to that for California
non-Hispanic caucasians for the year1985, the midpoint of the study. It was
determined that at age 30, the Seventh-Day Adventists men had a life
expectancy seven years greater than the comparison population, giving them
an average expected age at death of 81.2 years. Women could expect nearly
four and one half years more life than the comparison group, anticipating a
lifespan of 83.9 years. The vegetarians in the group could expect an
additional two years. The researchers concluded that the combination of
diet, exercise, body mass index, smoking habits and, in women, hormone
replacement, appear to account for up to ten years of increased life
expectancy in the Seventh Day Adventists, providing them with possibly the
highest life expectancy of any group studied, including the Japanese. Since
this population has no biological differences from the comparison group,
their increased life expectancy can be attributed to personal behaviors.
For most of us wishing to live longer, an extra ten years is of inestimable
value, and our own choice.

Free radical fighter studied

MetaPhore Pharmaceuticals has developed a drug that mimics the effects of
superoxide dismutase or SOD, one of the body's own highly potent
antioxidants. The drug, M40403, was recently shown in an clinical trial to
be safe and well tolerated. The trial was a first, as no small molecule
drugs that imitate antioxidant enzymes have previously been tested on
humans. Efficacy studies will follow.
Superoxide dismutase is an enzyme that scavenges the damaging superoxide
radical. Superoxide has been found to be overproduced by the body in cancer
and other diseases. The body's production of SOD subsequently becomes
inadequate, allowing the superoxide radical to react with other molecules,
damaging tissue.

The next study will utilize the drug in combination with interleukin-2 in
patients with end stage kidney cancer and advanced melanoma. Studies in
models of cancer have demonstrated that M40403 limits the drop in blood
pressure caused by interleukin-2 and appears to increase its tumor-fighting
ability. Side effects of high-dose interleukin-2 therapy can be
life-threatening and usually require that the patient receiving it be
treated in an intensive care unit. Some individuals are unable to complete
their course of treatment.


The concept of taking actions now to maintain youthful health is based on
published scientific studies showing that the diseases of aging may be
prevented, or can at least be postponed. People who want to reduce their
risk of disease are often overwhelmed by the volume of technical data on the
subject. The Life Extension Foundation has reviewed more than sixty-four
years' worth of published medical literature, and Foundation personnel have
spent more than thirty-five years working with physicians and scientists in
the antiaging field.

Before you embark on a program to reduce your risk of degenerative disease,
it is important for you to know about scientific studies conducted on humans
that show these therapies really work. If you are not aware of these
published studies, you may be unlikely to methodically follow a long-term
disease prevention program.

Hundreds of research studies have been published documenting the health
benefits of antioxidants. Antioxidants protect the body against agents of
disease called free radicals, which cause chemical reactions (oxidation)
that destroy cells and damage tissues. Oxidation is thought to be not only
one of the most common mechanisms of disease, but also a basis of the aging
process. Free radicals cannot be avoided; ultraviolet light, for example, is
a common source. Therefore, it is essential to take antioxidants in order to
counteract this process and prevent the degenerative diseases of aging.

Life Extension Mix supplies potent doses of the most powerful antioxidants:
vitamins C and E and vegetable extracts, which are known to repair the
cellular damage that accumulates with age. Studies have shown a variety of
health benefits for antioxidants. Research data have demonstrated
consistently that cancer risk is decreased by antioxidants, especially
vitamin C and lycopene. Beta-carotene helps offset the damage caused by
environmental pollutants. Both vitamins C and E prevent the oxidation of
"bad" LDL fat cells that leads to the buildup of fatty deposits inside
arteries (atherosclerosis). The Cambridge Heart Antioxidant Study reported
that those people with documented heart disease who took vitamin E
significantly decreased their risk of heart attack. Another recent study
found that vitamin E slows the loss of potency of the immune system that
occurs with age. Vitamin E may also improve brain function. The Life
Extension Mix makes it easy to ensure that you get the proper amounts of
these compounds that from diet alone are impossible to obtain.


Life Extension Mix

Life Extension Mix contains pharmaceutical-quality ingredients from the most
expensive suppliers. Commercial companies are increasingly importing cheap
Chinese raw materials, but Life Extension Mix continues to use
premium-quality ingredients from the following suppliers:

Vitamin C Roche or BASF
Lycopene Lyc-o-mato
Vitamin E (natural) Henkel
Grapeseed Extract Leucoselect
Selenium Nutrition 21
B-complex Roche
Beta-carotene (natural) Henkel

Life Extension Mix is an antioxidant formula that affords a considerable
degree of protection against free radicals. In addition, Life Extension Mix
includes nutrients that: enhance methylation (an essential process that
declines during aging); inhibit glycosylation (a significant cause of aging
damage); suppress apolipoprotein serum levels (a cause of atherosclerosis);
suppress homocysteine serum levels ( a cause of cardiovascular disease);
suppress mitochondrial oxidative stress (a cause of premature aging);
protect against thrombosis (abnormal blood clotting inside arteries);
maintain microcapillary perfusion; and protect against DNA mutations that
lead to certain cancers.


A large body of published evidence has now established that oxidative
modifications of proteins [carbonylation, etc.] occur during aging and in a
variety of pathophysiologic conditions, many being neurodegenerative
diseases including Alzheimer's disease.

Carbonylation is caused by aldehydes that can be neutralized by
supplementation with carnosine and by increasing glutathione at the cellular
level with alpha lipoic acid.

In addition to protecting against carbonylation, it is crucial to maintain
youthful mitochondrial energy production and immune function.
Acetyl-L-carnitine facilitates cellular energy production, while nettle leaf
extract suppresses high levels of a pro-inflammatory cytokine called tumor
necrosis factor alpha (TNF-a) believed to be a cause of immune senescence
(decline of the immune system in aging).

ChronoForte is a multi-ingredient antiaging supplement that provides the
best documented nutrients to protect against carbonylation and a host of
other newly identified aging factors.

Don't miss the opportunity to chat live with Dr Andrew Baer, Monday, July 23
at 7:00 pm and 10:00 pm Eastern Time. Participants will have the unique
opportunity to learn about integrative medicine and ask health related
questions. Visit
html to view Dr Baer's video.

Visit our website at www.lef.org and take part in our weekly survey. This
week's question: What is your primary concern with online shopping?

If you have any questions or comments concerning this issue or past issues
of Life Extension Update, send them to ddye@lifeextension.com

For longer life,

Dayna Dye
Editor, Life Extension Update
Life Extension Foundation
1 800 841 LIFE

This archive was generated by hypermail 2b30 : Fri Oct 12 2001 - 14:39:50 MDT