Re: telomerase: a new perspective

From: Damien Broderick (
Date: Mon Aug 21 2000 - 00:38:09 MDT

At 02:15 AM 21/08/00 -0400, Don Klemencic wrote:

>It appears that the 'dark side' of
>telomerase is manifested only when cells regain telomerase after having been
>previously damaged by its absence.

I'd have thought: more often, damaged in certain relevant oncogenic ways by
disruptive chemicals, oxidative stress, radiation mutation, etc.
(`accelerators' jammed on, `brakes' knocked out). But it would certainly be
interesting to know how much tumor-conducive damage is caused by copying
errors and the like due to telomere erosion in frequently-replaced cells.

Damien Broderick

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