Re: Werner's syndrome may have nothing to do with normal aging

From: Robert J. Bradbury (
Date: Fri Jul 21 2000 - 16:25:25 MDT

On Fri, 21 Jul 2000, Doug Skrecky wrote:

Quoting a Univ. of Washington Study:
> Thus, unlike the APOE polymorphism,
> there is no evidence of an association of this WRN
> polymorphism with longevity.

This was one of the problems I had with the work that was being
done at Aeiveos Sciences Group. There is no clear way of knowing
if lifespan decreasing genes are defective variants of lifespan
extending genes. They may very well not be. Conversely if
you are genotyping long-lived individuals, you have no way
of knowing whether you will discover the lifespan extending
genes or simply the lack of those mutations that in fact
result in disease predispositions that shorten lifespan.


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