serum glutathione predicts CHD

From: Doug Skrecky (
Date: Tue Jul 11 2000 - 23:39:14 MDT

  Serum glutathione in
  adolescent males predicts parental coronary heart disease.
  Circulation. 100(22):2244-7, 1999 Nov 30.
  BACKGROUND: Traditional risk factors account for only half of the morbidity
  and mortality from coronary heart disease (CHD). There is substantial
  evidence that oxidative injury plays a major role in the atherosclerotic
  process. Thus, antioxidants may protect against development of
  atherosclerosis. Glutathione, an intracellular tripeptide
  with antioxidant properties, may be protective. METHODS AND RESULTS: This
  case-control study compared total serum
  glutathione (tGSH) in 81 adolescent male
  offspring of parents with premature CHD (ie, before 56 years of age) and 78
  control male offspring of parents without known or suspected CHD. Case
  offspring had significantly lower tGSH than control offspring. In multiple
  logistic regression with parental CHD status as the dependent variable, age
  entered as a covariate, and other CHD risk factors competing to enter the
  model as significant independent predictor variables, LDL cholesterol (odds
  ratio [OR], 2.15 [units=1.5 SD]; 95% CI, 1.21 to 3.82), tGSH (OR, 0.40; 95%
  CI, 0.22 to 0.71), HDL cholesterol (OR, 0.42; 95% CI, 0.22 to 0.78), and
  total serum homocysteine (OR, 2.6; 95% CI, 1.35 to 5.02)
  entered the model as significant predictors of parental CHD status.
  CONCLUSIONS: Low tGSH in adolescent boys is a significant
  independent predictor of parental CHD, in addition to elevated LDL
  cholesterol, low HDL cholesterol, and elevated total serum
  homocysteine concentrations.

This archive was generated by hypermail 2b29 : Mon Oct 02 2000 - 17:34:24 MDT