Re: ACE inhibitors & hypoglycemic agents as LE drugs

From: phil osborn (
Date: Sun Jul 09 2000 - 01:18:35 MDT

>From: (James Ganong)
>Subject: ACE inhibitors & hypoglycemic agents as LE drugs
>Date: Fri, 7 Jul 2000 04:50:51 -0700 (PDT)
>ACE inhibitors are good for reducing mortality & morbidity from
>disease, but other than this I know of no direct LE benefits.
>Hypoglycemic agents might have some benefit in LE programs by reducing
>the formation of AGEs, but dietary modification is probably as effective
>for nondiabetics, without risking the adverse side effects.
What are the side effects?

>The real promise lies with drugs like aminoguanidine that can reverse
>damage from AGEs.
What are the side effects from aminoguanidine? I keep seeing references to
"toxicity," but nothing further.>

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