Re : Cornering the causes of aging (was Re: AGING: Accumulation of DNAdamage)

From: Joao Pedro de Magalhaes (
Date: Sun Jul 02 2000 - 08:40:30 MDT


phil osborn wrote:
>Nicely put. Wish you had been available twenty years ago to debate the then
>gurus of life extension. This was also W. Donner Denkla's position, BTW,
>but the problem was that the prior generations couldn't think very well in
>terms of "systems." They refused to see beyond the genetic driving force of
>the individual survival. Thus, they utterly rejected out-of-hand any
>arguments for the existence of a "death gene," or "aging clock." Thus, no
>research followup on Denkla's work.

I'm familiar with Denckla's work (I heard from one of his former
collaborators many interesting results they never published). However, I
heard Denckla himself is in the mountains of Virginia hearing spirits and
speaking to little green man! Is this true? Either he's a visionary or a
complete lunatic. Some species certainly have death genes in the form of
upregulating hormonal cascades; despite unlikely, perhaps human aging has
similar causes too (as I said before, I think human aging is probably a
simple mechanism).


Joao Pedro de Magalhaes
The University of Namur (FUNDP)
Unit of Cellular Biochemistry & Biology
Rue de Bruxelles, 61
B-5000 Namur BELGIUM

Fax: + 32 81 724135
Phone: + 32 81 724133
Reason's Triumph:

This archive was generated by hypermail 2b29 : Mon Oct 02 2000 - 17:33:49 MDT