PBN increases lifespan in mice

Doug Skrecky (oberon@vcn.bc.ca)
Sat, 12 Jun 1999 09:16:55 -0700 (PDT)

(Dr Proctor holds the patents on PBN)

From: pproctor@neosoft.com (Peter H. Proctor) Newsgroups: sci.life-extension,misc.health.alternative

Here is a favorite PBN paper from the National Institute on Aging. Note that it is effective from drinking water. BTW, 24 months is fairly elderly for a mouse.

Peter H. Proctor, PhD, MD

Also see more on PBN at http://www.nitrone.com

Biosci Biotechnol Biochem 1998 Apr;62(4):792-4

A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice.

Saito K, Yoshioka H, Cutler RG
Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA.

To characterize the pharmacological effects of N-tert-butyl-alpha-phenyl nitrone (PBN) on life span, we administered PBN in drinking water to 24.5 -month-old mice, and the survivors were counted. Their water consumption and body weights were measured as biological markers. PBN-treated animals as compared with control animals had prolonged mean and maximum life spans. Their water consumption decreased but no significant change was found in their body weights, indicating that the metabolism was improved. Results showed that PBN indeed affects physiological functions and extends life span. We propose that nitric oxide release from PBN may be involved in altering the aging process.