deprenyl increases mortality

Doug Skrecky (
Fri, 4 Jun 1999 01:20:26 -0700 (PDT)

Gallagher IM. Clow A. Glover V.
Department of Paediatrics, Queen Charlotte's & Chelsea Hospital, London, United Kingdom.
Long-term administration of
(-)-deprenyl increases mortality in male Wistar rats.
Journal of Neural Transmission. Supplementum. 52:315-20, 1998. Abstract
Long-term administration of the monoamine oxidase inhibitor (-)-deprenyl (0.5 mg/Kg) for up to 20 months significantly increased mortality in the male Wistar rat, whereas the dopamine agonist pergolide (0.4 mg/Kg) and the antioxidant diethyldithiocarbamate (400 mg/Kg) had no significant effect on mortality. The increased mortality was not related to dietary intake or body weight of the rats. This is of interest in the light of recent evidence that
(-)-deprenyl increases mortality in humans.