At 10:57 AM 4/9/98 -0400, you wrote:
>Dear John,
>
>This is from todays NY Times which is on the net at:
>
><http://www.nytimes.com/yr/mo/day/news/national/sci-vitamin-c.html>
>
>And no doubt in the NY city edition too.
>
>It is articles like these which always PRECEED the new set of guidelines
>which have squeezed the supplement business nearly out o existence here.
>
>Regards,
>Ron
Thanks for sending this, Ron. I didn't respond sooner because I was really
busy. LEF saw the article right away and wrote the following rebuttal- I
hope to get more input on this from Dick Passwater,PhD, Mathias Rath,MD,
Abram Hoffer, MD,PhD and others:
Life Extension Foundation's Preliminary
Rebuttal to a Recent Vitamin C Study
April 9, 1998
HIGH DOSES OF VITAMIN C CAUSE DAMAGE
On April 8, 1998, British scientists released the results of a
study showing that vitamin C was effective for cancer prevention and
free radical suppression at the dose of 60 mg a day, but at 500 mg a
day, it caused genetic damage that could lead to cancer or rheumatoid
arthritis.
The researchers gave 30 human volunteers 500 mg vitamin C supplements
for six weeks. The scientists showed that while 500 mg a day produces
protective effects, it also appears to have a dual activity in which
it can also cause damage.
Higher doses of vitamin C were shown to react with iron and other
metals to damage cellular DNA.
This small study help to validate The Life Extension Foundation's
17-year position that vitamin C must be taken with other antioxidants
like vitamin E, or the vitamin C will react with iron and copper to
produce DNA-damaging free radicals.
Saul Kent, President of The Life Extension Foundation, first brought
out this information in 1978, when he cited animal studies showing
that high doses of vitamin C, given without other antioxidants,
actually shortened the life span.
Most vitamin supplement users consume at least 400 iu of vitamin E,
and 400 mcg of folic acid every day. The addition of these two nutrients
could have prevented the iron-induced DNA damage observed by the British
scientists. More specific antioxidants like n-acetyl-cysteine, grape-seed
and green tea extract would provide significant protection against DNA
damage induced as a result of vitamin C catalyzing with iron and copper.
The British scientists did note that even at the high dose of 500 mg
of vitamin C a day, it was preventing more damage than it was creating.
-John
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