Re: AGING: Accumulation of DNA damage

From: Scott Badger (
Date: Mon Jun 26 2000 - 17:21:47 MDT

--- "Robert J. Bradbury" <> wrote:
> It [cloning problems] does however in my mind
provide a significant
> amount of gravity
> for the DNA Damage theory as being a factor in the
> aging process.
> The developmental genes in an adult can accumulate
> mutations and
> you will never know it. But if you try to grow a
> new adult using
> those genes with accumulated mutations, then the
> results detailed
> above are a likely result. It also suggests that if
> DNA mutations
> are gradually causing deaths in the latent stem cell
> population
> in the body, that over time you will have less and
> less reserve
> capacity from which to renew yourself. Only if you
> can reactivate
> the program that *expands* the remaining subset of
> "perfect" stem cells
> (as probably happens during development) will you be
> able to
> revserse this aspect of the aging process.

You've probably taken this into consideration, but
would Dr. West's research tend to refute this

"Now, in a major new paper published in the April 28,
2000 issue of the journal Science (1), a group led by
Dr. Michael West has reported what may be the most
revolutionary advance in cloning research so far. They
have found that cloning can totally reverse cellular


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