Re: Telomeres and stuff

Date: Mon May 01 2000 - 10:36:44 MDT

In a message dated 5/1/00 7:07:26 AM Pacific Daylight Time, writes:

> Wasn't there a report
> (perhaps from Univ. of Hawaii?) that telomerase knockout mice *do*
> show signs of inability to develop and/or accelerated aging after
> 3-4 generations?

In the study I saw, there were no alterations to aging through the fifth
generation: the 6th was sterile.

> If that is true, it might suggest that normal
> telomere lengths in adults would be sufficient to develop 2nd
> generation and perhaps even 3rd generation organs from stem cells
> remaining in the adult body, *without* the necessity of lengthening
> the telomeres through cloning or other processes.

But telomere lengths differ between organisms. Mice
have very long telomeres; we don't.

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